The number of synapses is a major determinant of behavior and many neural diseases exhibit deviations in that number.However, how signaling pathways control this number is still poorly understood.Using the Drosophila larval neuromuscular junction, we show here a PI3K-dependent pathway for synaptogenesis which is functionally connected with other pr
Objective To conduct hazard vulnerability analysis(HVA) in a blood bank, aimed to identify high-risk events and optimize emergency management measures.Methods The risk event evaluation index system was established by referring to the Kaiser model and the situation of Guangzhou Blood Center, and risk events were ranked by risk f1400ea-sb34 matrix an
There is empirical evidence that families have responded with much resilience and compassion to caring for persons living with AIDS (PWAs) in their homes (Engelbrecht & Kasiram, 2007; Sekokotla & Mturi, 2004; Simpson & Raniga, 2004).At the same time families in poverty-stricken communities are increasingly struggling and failing to provide optimall
BackgroundFood insecurity, limited access to adequate food, in adulthood is associated with poor health outcomes that suggest a pattern of accelerated aging.However, little is known about factors that impact food insecurity in midlife which in turn could help to identify potential pathways of accelerated aging.MethodsLow-income adults (n = 17,866;
Abstract HIV infection remains incurable as the virus persists within a latent reservoir of CD4+T cells.Novel approaches to enhance immune responses against HIV are essential for effective control and potential cure of the infection.In this study, we designed a novel tetravalent bispecific antibody (Bi-Ab32/16) to simultaneously target the gp120 vi